Table 6. Univariate and multivariate logistic regress analysis of the association of potential risk factors with poor treatment outcomes in MDR- and XDR-TB patients*.
| Potential risk factors | Patients with MDR-TB excluding XDR-TB | Patients with XDR-TB | ||||||
| Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||
| OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | OR (95% CI) | P | |
| Residence situation | ||||||||
| Beijing Resident | 1 | 1 | 1 | 1 | ||||
| Migrant | 1.90 (1.33, 2.71) | <0.001 | 1.77 (1.06, 2.96) | 0.030 | 4.32 (1.16,16.15) | 0.030 | 4.58 (0.69, 30.33) | 0.115 |
| Living area | ||||||||
| Rural area | 1 | 1 | 1 | |||||
| Urban area | 0.60 (0.42, 0.86) | 0.005 | 0.75 (0.46,1.24) | 0.265 | 0.50 (0.12, 2.15) | 0.351 | ||
| Lower lung field TB | 1.39 (0.98,1.97) | 0.067 | 1.07 (0.72,1.60) | 0.747 | 1.10 (0.29, 4.21) | 0.891 | ||
| Sites of TB | ||||||||
| Extrapulmonary TB | 1 | 1 | 1 | |||||
| Pulmonary TB | 1.91 (0.81,4.50) | 0.140 | 2.06 (0.31,13.64) | 0.454 | 5.50 (0.46, 66.32) | 0.180 | 1.04 (0.05, 24.19) | 0.981 |
| Smear-positivity at treatment onset** | 1.72 (1.06,2.80) | 0.027 | 1.94 (1.13, 3.34) | 0.016 | 6.72 (1.47, 30.76) | 0.014 | 10.42 (1.05,103.10) | 0.045 |
| Radiological findings at onset | ||||||||
| Non-cavitary | 1 | 1 | 1 | |||||
| Cavitary disease | 1.50 (1.06,2.12) | 0.022 | 1.49 (0.99,2.24) | 0.056 | 0.79 (0.22, 2.88) | 0.725 | ||
| Diabetes mellitus | 0.65 (0.37,1.14) | 0.131 | 0.73 (0.38,1.43) | 0.369 | 0.18 (0.02, 2.19) | 0.180 | 0.20 (0.01,3.38) | 0.263 |
| Hypertension | 0.32 (0.12,0.89) | 0.029 | 0.63 (0.20,1.96) | 0.423 | 1.73 (0.18,17.05) | 0.637 | ||
| 4 or more previous hospitalization for TB | 0.55 (0.27,1.13) | 0.103 | 0.53 (0.22,1.14) | 0.101 | 0.00 | 0.999 | ||
| Resistance to 3 or more first-line drugs | 1.52 (0.92,2.51) | 0.105 | 1.06 (0.59,1.89) | 0.852 | 0.76 (0.17,3.35) | 0.714 | ||
| Not receiving 3 or more potentially effective drugs | 2.77 (1.94,3.96) | <0.001 | 3.87 (2.53,5.91) | <0.001 | 8.57 (1.65, 44.43) | 0.010 | 14.90 (1.35, 164.94) | 0.028 |
TB = tuberculosis;
MDR = multidrug-resistant;
XDR = extensively drug-resistant.
OR = odds ratio.
CI = confidence interval.
*Variables included in the univariate analysis were shown in Table S1; All variables with a P value<0.2 in the univariate analysis were included in multivariate logistic regression analysis; 472 MDR-TB patients and 44 XDR-TB patients were included in multivariate logistic regression analysis. A P value of <0.05 was considered to be statistically significant.
**n = 477 for MDR-TB; n = 44 for XDR-TB.