Table 1. Demographic and clinical characteristics of subjects with RIS.

Subjects	Sex	Age	Family historyof MS	Age at first brain MRI	Reason for first brain MRI	Spinal cord MRI ∧	DIT at brain MRI	CSF *	VEPs #	Cognition $
1	M	45	No	44	Depression	−	−	−	−	+
2	F	51	No	50	Cervical Trauma	+	+	+	+	n.p.
3	M	37	No	35	Dermatitis	−	−	−	−	−
4	F	37	No	34	Headache	n.p.	−	+	−	−
5	M	43	Yes	42	Neuropathic pain	−	+	−	−	n.p.
6	F	46	Yes	40	MS family history	+	−	n.p.	−	+
7	F	23	No	21	Pituitary adenoma	+	+	+	n.p.	−
8	F	45	No	39	Cervical trauma	+	+	+	−	+
9	M	31	Yes	29	Headache	−	+	−	n.p.	−
10	F	38	No	31	Migraine with aura	−	+	+	−	−
11	F	23	No	22	Migraine without aura	+	+	+	+	−
12	M	46	No	45	Headache	n.p.	−	n.p.	−	−
13	F	28	No	23	Facial trauma	−	−	n.p.	n.p.	+
14	F	39	Yes	39	Otosclerosis	n.p.	−	n.p.	n.p.	−
15	F	19	No	19	Headache	+	+	+	+	−
16	F	41	No	40	Dizziness (<2 mins)	−	−	−	−	−
17	F	43	No	43	Anxiety	n.p.	−	+	−	−
18	F	34	No	34	Neck pain	+	+	+	−	−
19	F	31	No	28	Obesity	−	+	+	−	n.p.

n.p. =  not performed.

DIT =  dissemination in time.

CSF =  cerebrospinal fluid.

See text for other abbreviations.

^∧+: presence of cervical spine lesion; -: absence of signal abnormalities.

*+: presence of oligoclonal bands and/or abnormal IgG Index; -: normal pattern.

^#+: presence of abnormal P100 in at least one of the eyes; -: normal pattern.

^$+: failure of ≥2 tests at the Rao Brief Repeatable Battery; -: failure of ≤1 test.