Figure 2.

Activation of a human β-globin locus transgene in KLF1 null mouse mutants. RNA expression levels of the human β-like globins [embryonic (ɛ), fetal (γ), adult (β)] were assessed by quantitative S1 nuclease protection assays.⁶ Days of mouse embryonic development are indicated (E10.5, E12.5, E14.5). The status of the mouse KLF1 alleles is shown: wt = wild-type; het = heterozygous for KLF1 null allele, null = homozygous for KLF1 null allele. Data courtesy of Drs. Beatriz Nuez and Frank Grosveld.