Table 3.

Effect of MTA on the toxicity of 5-FU in NCr-nu/nu mice

	Treatment group	Deaths	Day of death
1	100 mg/kg MTA	0
2	200 mg/kg 5-FU	3/3	(8, 9, 10)
3	100 mg/kg MTA plus 200 mg/kg 5-FU	0/3
4	100 mg/kg MTA plus 200 mg/kg 5-FU	0/3

Female NCr-nu/nu mice were injected ip with the above compounds once on days 1, 5, 9 and 13 (q4dx4). In this experiment, MTA was administered twice (60 and 15 min) prior to injection of 5-FU (group 3) and it was also administered 30 min before 5-FU and 30 min after 5-FU (group 4).