Figure 7. Thorase is required for spatial working memory.

(A, B, and C) Open field assessments in Thorase conditional knockout mice (cKO, Thorase^{Flox/Flox, iCre +}, n = 20) versus WT littermates (WT, Thorase^{+/+, iCre +}, n = 19, mean ± S.E.M).

(A) Central activity.

(B) Peripheral activity.

(C) Rearing activity. Significance between cKO and WT mice was determined, *p < 0.05, two-way ANOVA.

(D, E, F and G) Elevated plus maze testing in cKO versus WT littermates. No significant difference as determined by a Two-way ANOVA was found between cKO and WT (mean ± S.E.M).

(D) Total travel distance.

(E) Percent time in open arms.

(F) The percentage of entries into open arms.

(G) Number of rears.

(H) Mean percent correct spontaneous alternation ± S.E.M for cKO (n = 8) or WT (n = 9) mice in a Y maze, *p < 0.05, Student’s t-test.

(I) Mean percent time ± S.E.M. spent in a previously blocked arm in the first 2 minutes during the second acquisition phase of the Y maze, *p < 0.05, Student’s t-test.

(J) Mean percent correct rewarded alternation ± S.E.M for Thorase cKO (n = 8) and WT (n = 9) mice during spatial non-matching to place testing on the elevated T maze, *p < 0.05, two-way ANOVA with Tukey-Kramer post-hoc test.

See also Figure S5.