Table 1.
Comparisons between sirolimus-treated and control mice on average tumor volume in an established xenograft tumor model
| Day | Study groups (n=5) Mean±SD, 95% confidence range |
p-value vs. corresponding control | p-value vs. historical data on Temsirolimus18 |
|---|---|---|---|
| Control | |||
| Day 0 | 55.7±15.2, 38.2 – 76.9 | ||
| Day 7 | 176.8±85.6, 54.8 – 282.5 | ||
| Day 14 | 460.0±262.2, 105.3 – 832.3 | ||
| Day 21 | 684.0±439.0, 143.9 – 1349 | ||
| Rapamycin = 5 mg/kg | |||
| Day 0 | 56.4±19.2, 33.7 – 74.0 | 0.92 | 0.92 |
| Day 7 | 71.8±11.4, 55.0 – 84.5 | 0.12 | 0.60 |
| Day 14 | 96.4±25.1, 68.2 – 127.6 | 0.03* | 0.60 |
| Day 21 | 106.8±28.4, 72.3 – 139.9 | 0.009** | 0.60 |
| Rapamycin = 10 mg/kg | |||
| Day 0 | 56.0±9.3, 42.3 – 66.5 | 0.92 | 0.60 |
| Day 7 | 57.3±28.5, 32.5 – 94.5 | 0.03* | 0.009** |
| Day 14 | 78.1±19.5, 50.5 – 101.4 | 0.009** | 0.009** |
| Day 21 | 102.1±22.7, 78.4 – 126.2 | 0.009** | 0.009** |
| Rapamycin = 15 mg/kg | |||
| Day 0 | 55.1±12.6, 36.9 – 69.3 | 0.92 | 0.60 |
| Day 7 | 68.9±7.6, 60.1 – 81.1 | 0.12 | 0.12 |
| Day 14 | 106.3±10.1, 99.2 – 123.9 | 0.02* | 0.12 |
| Day 21 | 155.4±27.3, 112.3 – 187.5 | 0.04* | 0.07 |
| Rapamycin = 20 mg/kg | |||
| Day 0 | 55.9±9.1, 49.2 – 70.3 | 0.92 | 0.92 |
| Day 7 | 51.1±16.1, 22.8 – 63.3 | 0.04* | 0.12 |
| Day 14 | 78.6±29.2, 41.1 – 122.7 | 0.02* | 0.75 |
| Day 21 | 114.4±56.4, 65.4 – 109.8 | 0.02* | 0.60 |
*
Significant difference at 5% level (0.01<p-value<0.01
**
Significant difference at 1% level (p-value<0.01)