Table 2.
Disease severity and depressive symptoms in relation to NPI-Q-assessed NSD in DLB and AD patients
| DLB (n = 339) |
Probable AD (n = 4,192) |
|||||||
|---|---|---|---|---|---|---|---|---|
| without NSD (n = 125) | with NSD (n = 214) | test statistic | p value | without NSD (n = 3,077) | with NSD (n = 1,115) | test statistic | p value | |
| MMSE score (mean ± 1 SD) | 23.0 ± 16.9 | 24.0 ± 16.5 | F1, 337 = 0.29 | 0.59 | 21.6 ± 14.4 | 21.7 ± 16.7 | F1, 4,190 = 4.3 | 0.037 |
| CDRSOB | 6.9 ± 5.1 | 7.2 ± 4.5 | F1,337 = 2.0 | 0.15 | 6.7 ± 4.3 | 8.0 ± 4.7 | F1, 4,190 = 70 | <0.001 |
| NPI-Q depression item, % | 45 | 52 | χ21 = 1.8 | 0.18 | 33 | 48 | χ21 = 74 | <0.001 |
| GDS | 4.3 ± 3.4 | 4.5 ± 3.3 | Fl,283 = 0.63 | 0.43 | 2.3 ± 2.5 | 2.7 ± 2.7 | F1, 3,653 = 18 | <0.001 |
MMSE = Mini-Mental State Exam. Continuous variables are summarized with mean ± 1 standard deviation and categorical variables by percentages, p values represent comparisons using the Wilcoxon (for continuous variables) or Pearson's test (for categorical variables). For GDS: 3,655 (87%) and 285 (84%) responses noted for probable AD and DLB, respectively.