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. Author manuscript; available in PMC: 2011 May 1.
Published in final edited form as: Pharm Res. 2009 May 5;26(8):1838–1846. doi: 10.1007/s11095-009-9893-3

Fig. 6.

Fig. 6

Efficacy of locally delivered Ranpirnase, Amphinase and ACC7201 in the intracranial 9L glioma rodent model.

Rodent 9L gliosarcoma was excised from the flanks of carrier rats and cut into 1-mm3 pieces, which were then implanted into the brain. The piece tumor tissue was implanted first and then the polymeric formulation was inserted adjacent to it. The polymeric formulation was implanted either simultaneously or 5 days after implantation of the tumor piece.

Implants (30 mg) contained A) Ranpirnase 0.05% w/w w/w poly(SA-RA), B) Amphinase 5% w/w poly(SA-RA) 3:7. and C) ACC7201 4% w/w (n=16 per group).