Figure 5.
Reversal of the anxiogenic-like effects of citalopram (CIT) and increased locomotor activity by combination with diazepam (DZ) in male BALB/c mice. Data are mean ± SEM of behavioral measures following acute citalopram treatment (30 mg/kg, i.p.), alone and combined with several doses of diazepam (0.3–10 mg/kg, i.p.) to separate groups of mice. Sample sizes were n=6 (control), n=7 (citalopram alone, 0.3 mg/kg diazepam + citalopram), and n=8 (1.0 mg/kg diazepam + citalopram, 3.0 mg/kg diazepam + citalopram). Note that *p<.05 vs. control and #p<0.05 vs. citalopram alone, Holm-Sidak test.