Table 2.
Sensitivity analyses of FibroTest diagnostic values according to patient characteristics
| Advanced fibrosis | Pairwise comparisons between all stages, Obuchowski measure | ||
|---|---|---|---|
| Characteristic (no. of patients) | Not standardized AUROC | Significance (P) | AUROC (95% CI) |
| All (1303) | 0.76 (0.73–0.79) | 0.844 (0.832–0.856) | |
| Gender | >0.10 | ||
| Male (941) | 0.75 (0.72–0.78) | ||
| Female (362) | 0.76 (0.70–0.81) | ||
| Length of biopsy | >0.10 | ||
| <25 mm (942) | 0.76 (0.71–0.85) | ||
| ≥25 mm (148) | 0.79 (0.71–0.85) | ||
| Not available (213) | 0.76 (0.69–0.82) | ||
| Ethnicitya | 0.06 | P > 0.10 | |
| Asian (546) | 0.72 (0.67–0.76) | 0.836 (0.814–0.848) | |
| Caucasian (601) | 0.78 (0.74–0.82) | 0.853 (0.839–0.867) | |
| Sub-Saharan (156)b | 0.80 (0.72–0.86) | ||
| HBeAgc,d | 0.046 | P > 0.10 | |
| Absent (548) | 0.73 (0.68–0.77)e | 0.854 (0.838–0.870) | |
| Present (753) | 0.78 (0.75–0.82) | 0.831 (0.814–0.848) | |
| After treatment | >0.10 | ||
| No (723) | 0.75 (0.71–0.78) | ||
| Yes (392) | 0.78 (0.72–0.82) | ||
| Not available (188) | 0.78 (0.70–0.85) | ||
| HBV genotype | >0.10 | ||
| Genotype A (61) | 0.77 (0.57–0.88) | ||
| Genotype non-A (137) | 0.77 (0.73–0.79) | ||
| Not available (1105) | 0.76 (0.73–0.79) | ||
| Viral load (IU/mL) | >0.10 | ||
| <3 Log (276) | 0.79 (0.73–0.84) | ||
| 3–5 Log (115) | 0.82 (0.72–0.88) | ||
| 5–7 Log (330) | 0.72 (0.66–0.77) | ||
| >7 Log (464) | 0.77 (0.72–0.81) | ||
| Not available (118) | 0.76 (0.65–0.83) | ||
| ALT <50 IU/L | >0.10 | ||
| No (825) | 0.75 (0.72–0.79) | ||
| Yes (478) | 0.76 (0.70–0.80) | ||
| ALT <25 IU/L | >0.10 | ||
| No (1151) | 0.76 (0.73–0.79) | ||
| Yes (152) | 0.72 (0.57–0.82) |
aIn Asian patients (n = 546) the overall mean (95% CI) accuracy of FibroTest (standardized using Obuchowski measure) was 0.827 (0.807–0.846), no different than that of non-Asian (n = 757), 0.853 (0.839–0.867), (NS)
bAfrican American also included
cIn 2 patients, status was unknown
dIn patients with presence of HBeAg (n = 753) the overall mean (95% CI) accuracy of FibroTest (standardized using Obuchowski measure) was 0.831 (0.814–0.848), no different than that of patients without HBeAg (n = 548), 0.854 (0.838–0.870), (NS)
e P = 0.046 vs “present”
ALT alanine aminotransferase, AUROC area under the receiver operating curve, HBeAg hepatitis B early antigen, HBV hepatitis B virus