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IC50 values for 12 and oleanolic acid derivative 1 with human cancer cell lines.[a]
| Cell line | 12 | 1 |
|---|---|---|
| KB-3-1 | 0.3±0.08 | 1.2±0.16 |
| KB-8-5 | 1.2±0.12 | 3.1±0.29 |
| HeLa | 1.3±0.28 | 2.8±0.37 |
| MCF-7 | 5±0.34 | >10 |
| SK-N-MC | 0.8±0.1 | 4.9±0.6 |
IC50 was defined as the compound concentration that resulted in 50 % cell survival as measured by the MTT assay (see Experimental Section). Incubation time: 24 h.
