TABLE III.
Results of 15 Candidate Genes for Intelligence in the IMAGE Cohort
| GENE | Previous associated SNP (G/I)a | P-value with previous associated SNP | nSNPs tested | Coverage | SNP density, kb/SNP | nSNPs, P < 0.05 | Most significant SNP (G/I)a | Position | Type | Best P-value |
|---|---|---|---|---|---|---|---|---|---|---|
| DNAJC13 | rs1378810 (I) | 0.642 | 45 | 1 | 31.41 | 0 | rs12637073 (I) | 133666251 | Intronic | 0.096 |
| TBC1D7 | rs2496143 (I) | 0.8568 | 47 | 1 | 9.20 | 0 | rs480122 (G) | 13425063 | Intronic | 0.588 |
| DTNBP1 | rs1018381 | — | 65 | 1 | 24.55 | 5 | rs760666 (G) | 15589121 | Intronic | 0.020 |
| ALDH5A1 | rs2760118 (I) | 0.8328 | 46 | 1 | 13.52 | 1 | rs2760138 (I) | 24620816 | Intronic | 0.047 |
| IGF2R | rs3832385 | — | 88 | 0.967 | 18.62 | 5 | rs8191898 (I) | 160418955 | Intronic | 0.018 |
| CHRM2 | rs8191992 | — | 81 | 0.942 | 21.10 | 2 | rs6467694 (G) | 136197456 | Upstream | 0.010 |
| rs1378650 (G) | 0.8284 | |||||||||
| rs1424548 (I) | 0.3888 | |||||||||
| rs2350780 (I) | 0.9788 | |||||||||
| rs2350786 (G) | 0.6316 | |||||||||
| rs6948054 (I) | 0.322 | |||||||||
| rs7799047 | — | |||||||||
| rs324640 | — | |||||||||
| rs324650 (I) | 0.2514 | |||||||||
| rs2061174 | — | |||||||||
| BDNF | rs6265 (G) | 0.1018 | 29 | 1 | 29.86 | 2 | rs12288512 (I) | 27704247 | Upstream | 0.011 |
| CTSD | rs17571 (G) | 0.2932 | 6 | 1 | 59.01 | 0 | rs3740621 (I) | 1728373 | Upstream | 0.081 |
| FADS3 | rs174455 (I) | 0.6665 | 9 | 0.875 | 41.54 | 0 | rs174626 (G) | 61393633 | Downstream | 0.050 |
| DRD2 | rs2075654 | — | 57 | 0.982 | 15.02 | 2 | rs4630328 (I) | 112839419 | Intronic | 0.047 |
| KL | rs9536314 (G) | 0.6873 | 52 | 0.933 | 13.39 | 0 | rs17763040 (G) | 32543384 | Intergenic | 0.142 |
| SNAP25 | rs362602 (G) | 0.2254 | 71 | 0.913 | 0 | rs362990 (G) | 10224221 | Intronic | 0.063 | |
| rs363039 (I) | 0.6062 | |||||||||
| rs363050 (G) | 0.3723 | |||||||||
| PRNP | rs1799990 (G) | 0.944 | 21 | 0.778 | 20.63 | 0 | rs6084833 (I) | 4620759 | Intronic | 0.135 |
| CBS | rs5742905 | — | 22 | 0.675 | 19.83 | 0 | rs1788490 (I) | 43340620 | Intergenic | 0.189 |
| COMT | rs4680 (G) | 0.6209 | 33 | 0.633 | 14.62 | 0 | rs9332377 (I) | 18335692 | Intronic | 0.08 |
Genome build 36.
a
G and I indicate genotyped and imputed SNPs, respectively.