TABLE IV.
Replication Results in the Genomic Loci Previously Associated With Intelligence in the IMAGE Cohort
| SNP (G/I)a | Minor/major allele | MAF | Rank | P-value | Chr | Position | Type | Closest gene | Distance to gene |
|---|---|---|---|---|---|---|---|---|---|
| Genomic location 2q24.1-31.1 (from 154475832 to 177730691 bp) total SNPs tested = 7,819 in 182 genes | |||||||||
| rs4972741 (I) | G/A | 0.12 | 1 | 0.00017 | 2 | 172823906 | Intergenic | AC104088.1 | −64,355 |
| rs6721348 (I) | C/T | 0.12 | 2 | 0.00018 | 2 | 172826755 | Intergenic | AC104088.1 | −61,506 |
| rs10172929 (G) | G/T | 0.13 | 3 | 0.00031 | 2 | 164756952 | Intergenic | AC092684.1 | 0 |
| rs16844374 (G) | C/T | 0.15 | 7 | 0.00127 | 2 | 160394348 | Intronic | LY75 | 0 |
| rs10201330 (I) | T/C | 0.09 | 4 | 0.00132 | 2 | 177056271 | Intergenic | AC017048.3 | 22,948 |
| rs4289149 (G) | A/G | 0.18 | 8 | 0.00150 | 2 | 172834736 | Intergenic | ITGA6 | 165,264 |
| rs995711 (G) | G/T | 0.12 | 5 | 0.00174 | 2 | 164123635 | Intergenic | FIGN | −34,517 |
| rs11896469 (G) | C/T | 0.44 | 6 | 0.00230 | 2 | 176388492 | Intergenic | EXTL2P1 | 27,369 |
| Genomic location 6p25-21.2 (from 5945435 to 41007859 bp) total SNPs tested = 18,651 in 809 genes | |||||||||
| rs12204969 (I) | C/T | 0.12 | 1 | 0.00018 | 6 | 16802156 | Intronic | ATXN1 | 0 |
| rs17606216 (G) | C/T | 0.12 | 2 | 0.00018 | 6 | 16796594 | Intronic | ATXN1 | 0 |
| rs993600 (G) | G/A | 0.16 | 3 | 0.00027 | 6 | 22153623 | Within non-coding gene | RP1-67M12.1 | 0 |
| rs2023472 (G) | A/G | 0.42 | 4 | 0.00028 | 6 | 30183843 | Intergenic | TRIM31 | 5,241 |
| rs6929819 (G) | G/A | 0.43 | 5 | 0.00033 | 6 | 33670832 | Intergenic | C6orf227 | 1,739 |
| rs195371 (G) | G/A | 0.23 | 6 | 0.00034 | 6 | 37412364 | Intergenic | TBC1 | 3,464- |
| rs6929774 (I) | T/C | 0.42 | 7 | 0.00039 | 6 | 33670698 | Intergenic | C6orf227 | 1,605 |
| rs17606174 (G) | T/C | 0.13 | 8 | 0.00050 | 6 | 16795524 | Intronic | ATXN1 | 0 |
| Genomic location 14q11.2-12 (from 21269202 to 28322992 bp) total SNPs tested = 2,964 in 233 genes | |||||||||
| rs2807822 (I) | T/C | 0.47 | 1 | 0.00010 | 14 | 27554764 | Intergenic | AL445384.1 | 25,600 |
| rs3811222 (I) | A/G | 0.10 | 2 | 0.00066 | 14 | 22020854 | Intronic | TRAC | 0 |
| rs762578 (I) | T/G | 0.11 | 3 | 0.00069 | 14 | 22020088 | Intronic | TRAC | 0 |
| rs1872159 (G) | T/C | 0.09 | 4 | 0.00080 | 14 | 22017743 | Intronic | TRAC | 0 |
| rs7149201 (I) | C/T | 0.20 | 5 | 0.00178 | 14 | 23034259 | Intergenic | NGDN | 17,017 |
| rs877726 (G) | T/A | 0.23 | 6 | 0.00230 | 14 | 27557719 | Intergenic | AL445384.1 | −28,555 |
Only SNPs with a P < 0.0025 are shown.
Genome build 36.
a
G and I indicate genotyped and imputed SNPs, respectively.