TABLE V.

Meta-Analysis of the Top SNPs From the Primary Analysis

				IMAGE (N = 606)		DUKE (N = 216)		ALSPAC (N = 1,495)		QIMR (N = 1,670)		LBC1936 (N = 976)		IMAGE and DUKE (N = 822)		ALL (N = 4,963)
Gene	Genomic area	SNP	A	B	P	B	P	B	P	B	P	B	P	Z	P	Z	P
Intergenic	2q24.1-31.1	rs10172929	T	4.64	0.0003			0.23	0.84	−0.03	0.96	−0.94	0.35			0.95	0.34
Intergenic	2q24.1-31.1	rs10201330	T	5.43	0.0013			1.28	0.27	−0.76	0.38	0.19	0.88			1.32	0.19
CHRM2	7q33	rs10271552	T	−3.18	0.0398			−0.42	0.65	−0.23	0.76	−1.38	0.23			−1.72	0.09
Intergenic	2q24.1-31.1	rs11896469	T	2.55	0.0023			−0.01	0.71	0.47	0.32	−0.38	0.58			1.18	0.24
ATXN1	6p25-21.2	rs12204969	T	4.98	0.0002			−2.12	0.01	−0.99	0.14	0.49	0.61			0.65	0.51
BDNF	11p14	rs12273363	T	−2.61	0.0131	0.88	0.68	−0.42	0.54	0.13	0.82	0.70	0.43	−2.00	0.0456	0.95	0.34
BDNF	11p14	rs12288512	A	2.67	0.0114	−0.88	0.68	0.42	0.55	−0.13	0.82	−0.70	0.43	2.04	0.0410	1.32	0.19
LY75	2q24.1-31.1	rs16844374	T	3.77	0.0013
ATXN1	6p25-21.2	rs17606174	T	−4.47	0.0005	−3.95	0.16	0.12	0.02	0.40	0.53	−0.76	0.41	−3.80	0.0001	−0.22	0.83
ATXN1	6p25-21.2	rs17606216	T	4.91	0.0002			−2.15	0.01	−0.86	0.20	0.43	0.65			−0.67	0.51
IGF2R	6q26	rs1805075	A	−4.47	0.0189			−0.30	0.82	0.76	0.50	−0.62	0.71			−0.73	0.47
Intergenic	14q11.2-12	rs1872159	T	4.77	0.0008	2.61	0.46	−0.30	0.76	0.58	0.43	0.75	0.47	3.32	0.0009	1.92	0.06
Intergenic	6p25-21.2	rs195371	A	−3.65	0.0003			−0.14	0.00	0.62	0.28	−0.23	0.78			−2.41	0.02
TRIM31	6p25-21.2	rs2023472	A	−3.09	0.0003	−1.58	0.35	0.19	0.75	0.95	0.05	0.23	0.73	−3.65	0.0003	−0.25	0.80
DTNBP1	6p23	rs2619545	T	−2.34	0.0362	2.07	0.34	0.25	0.73	−0.34	0.56	0.87	0.30	−1.41	0.1589	−1.98	0.05
ALDH5A1	6p23	rs2760138	A	−3.05	0.0478
Intergenic	14q11.2-12	rs2807822	T	−3.63	0.0000	0.39	0.82	0.09	0.89	0.77	0.10	−0.19	0.78	−3.34	0.0009	0.54	0.59
Intergenic	14q11.2-12	rs3811222	A	5.15	0.0007	0.91	0.79	−0.47	0.68	0.59	0.41	0.98	0.33	3.16	0.0016	−1.87	0.06
Intergenic	2q24.1-31.1	rs4289149	A	3.36	0.0015	−3.52	0.14	0.00	0.99	1.18	0.05	−0.62	0.48	2.08	0.0380	1.67	0.10
DRD2	11q23	rs4630328	A	−1.79	0.0475			0.95	0.14	0.18	0.71	0.33	0.66			−0.74	0.46
Intergenic	2q24.1-31.1	rs4972741	A	−5.51	0.0002			−1.15	0.24	−0.23	0.78	0.80	0.51			−1.87	0.06
CHRM2	7q33	rs6467694	T	−3.86	0.0097	−1.47	0.59	0.92	0.32	1.11	0.14	−0.94	0.41	−2.54	0.0112	−0.73	0.47
DRD2	11q23	rs6589377	A	1.71	0.0504	−0.29	0.87	−0.92	0.13	−0.18	0.71	−0.53	0.46	1.65	0.0986	1.92	0.06
Intergenic	2q24.1-31.1	rs6721348	A	−5.51	0.0002			−1.09	0.26	−0.28	0.73	0.79	0.51			0.04	0.97
Intergenic	6p25-21.2	rs6929774	T	−3.09	0.0004	1.98	0.23	0.05	0.18	−0.63	0.19	0.43	0.53	−2.62	0.0089	−0.77	0.44
C6orf227	6p25-21.2	rs6929819	A	3.08	0.0003	−1.09	0.26	−0.05	0.20	0.65	0.18	−0.41	0.55	2.65	0.0081	0.86	0.39
Intergenic	14q11.2-12	rs7149201	T	3.72	0.0018	−2.30	0.42	0.36	0.62	−0.39	0.49	0.49	0.54	2.45	0.0144	1.10	0.27
DTNBP1	6p23	rs760666	A	−2.34	0.0223	0.87	0.69	−0.33	0.64	0.13	0.81	−0.11	0.90	−1.85	0.0644	−0.91	0.36
Intergenic	14q11.2-12	rs762578	T	4.62	0.0007	2.32	0.40	−0.31	0.73	0.73	0.29	0.27	0.79	3.40	0.0007	1.89	0.06
DTNBP1	6p23	rs7758659	T	−2.34	0.0225	0.88	0.69	−0.34	0.63	0.13	0.81	−0.11	0.89	−1.85	0.0648	−0.91	0.36
IGF2R	6q26	rs8191818	T	−4.49	0.0200	−2.79	0.35	−0.36	0.80	0.65	0.56	−0.47	0.78	−2.49	0.0126	−0.92	0.36
IGF2R	6q26	rs8191821	T	4.52	0.0196	2.79	0.35	0.34	0.80	−0.65	0.56	0.47	0.78	2.50	0.0124	0.92	0.36
IGF2R	6q26	rs8191898	T	4.47	0.0185	2.78	0.35	0.31	0.82	−0.76	0.50	0.47	0.78	2.52	0.0117	0.86	0.39
DTNBP1	6p23	rs875462	T	2.21	0.0318	−1.20	0.57	0.39	0.57	−0.17	0.76	0.59	0.47	1.64	0.1012	1.11	0.27
Intergenic	14q11.2-12	rs877726	A	−3.09	0.0023	−0.55	0.79	0.00	0.92	0.65	0.23	−0.41	0.59	−2.75	0.0059	−0.67	0.50
DTNBP1	6p23	rs9296983	A	−2.33	0.0229	0.87	0.69	−0.33	0.64	0.16	0.77	−0.11	0.90	−1.84	0.0657	1.10	0.27
IGF2R	6q26	rs9457827	T	4.47	0.0187	2.78	0.35	0.30	0.82	−0.76	0.50	0.62	0.71	2.52	0.0119	0.89	0.37
Non-coding gene	6p25-21.2	rs993600	A	4.11	0.0003	1.41	0.49	0.33	0.67	0.00	0.99	0.13	0.88	3.55	0.0004	1.71	0.09
Intergenic	2q24.1-31.1	rs995711	T	4.02	0.0018	2.16	0.44	1.19	0.25	−0.67	0.40	0.27	0.84	3.15	0.0017	1.47	0.14

A is the reference allele; B is the beta effect; P is the P-value, Z is the Z-statistic as provided in the meta-analysis.

Bold indicates below the Bonferroni corrected threshold of significance (<0.001) and same direction of effect in the meta-analysis.