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. Author manuscript; available in PMC: 2011 May 2.
Published in final edited form as: Carcinogenesis. 2006 Jan 12;27(7):1432–1444. doi: 10.1093/carcin/bgi345

Table I.

Parameterizations used in the model analyses

Model rates Parameters to
estimate		 Description
μ1(s) = μ01[1 + f(s; y1, y2)] μ0, y1, y2 First mutation rate
 (initiation)
μ2(s) = μ02[1 + f(s; m1, m2)] m1, m2 Rate of malignant
 transformation
ε(s) = α – β = ε0[1 + f(s; ε1, ε2)] ε0, ε1, ε2 Rate of net clonal
 expansion of I-cells

The model rates and their parameterizations are given together with the free parameters and a description of the model rates. The restriction μ01 = μ02 = μ0 is used together with N = 107.