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. 2011 Apr 25;3:1. doi: 10.3389/fnene.2011.00001

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Copyright © 2011 Kleinfeld, Blinder, Drew, Driscoll, Muller, Tsai and Shih.

This is an open-access article subject to a non-exclusive license between the authors and Frontiers Media SA, which permits use, distribution and reproduction in other forums, provided the original authors and source are credited and other Frontiers conditions are complied with.

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Ipsilateral versus contralateral electrophysiological and neurovascular responses to sensory input. (A) Schematic of neuronal pathways. The contralateral cortex receives input via brainstem (not shown) and thalamic relays. This input is further relayed to ipsilateral cortex via collosal projections. (B) Measured multiunit responses to electrical stimulation of the fore-limb; 500 stimulation trials were averaged. (C). Net vasodilation in surface cortical arterioles in response to somatotopic stimulation on the contralateral side (upper traces in each pair) but vasoconstriction in response to ipsilateral stimulation (lower traces). The stimulus-induced ECoG (red) identifies the locus of the electrical response. Adapted from Devor et al. (2008).