Table 3.

Viral expression cassettes for in vivo genetic manipulation of astrocyte and interneuronal signaling.

shRNA target	Pathway	Targeting strategies	References
mGluR	Astrocyte glutamate signaling pathway		Zonta et al. (2003)
phospholipase A2, cyclo-oxygenase-1, or cytochrome p450	Astrocyte arachidonic acid metabolism		Zonta et al. (2003); Mulligan and MacVicar (2004)
Ca2+ sensitive large conductance BK channels	Astrocytic potassium release		Filosa et al. (2006); Weaver et al. (2006); Girouard et al. (2010)
VIP or vascular receptor VPAC1	Interneuron VIP release	Cre-lox	Fahrenkrug et al. (2000); Cauli et al. (2004)
NOS	Interneuron NO release		Cauli et al. (2004); Enager et al. (2008)
SOM or vascular receptor SSTR	Interneuron SOM release		Cauli et al. (2004); Enager et al. (2008); Kocharyan et al. (2008)
NPY or vascular receptor NPY-Y1	Interneuron NPY release		Cauli et al. (2004)