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. Author manuscript; available in PMC: 2012 Aug 1.
Published in final edited form as: Behav Brain Res. 2011 Mar 21;221(1):324–328. doi: 10.1016/j.bbr.2011.03.028

Figure 1.

Figure 1

Homing response (HR) performance (A–D) and motor activity (E, F) in sham-intubated control (S) and alcohol-exposed (AE) rats with and without subsequent treatment with the orexin-1 receptor antagonist, SB-334867 (mean ± SE). The percentage of tests in which HR acquisition was not achieved (A), the shortest HR latency (C), and the number of trials needed to reach the shortest latency (D) were all higher, whereas the percentage of successful trials was lower (B), in AE than S group. Among the rats treated with SB-334867, these measures were not significantly different between AE and S rats, and all measures except the shortest HR latency were also not different between the AE group treated with SB-334867 and S group treated with vehicle. The total number of movements during 10 min period spent in a novel environment (E) and the number of bouts of stereotypic motor behaviors (F) were higher in AE rats subsequently treated with vehicle than in either the S group treated with vehicle or the AE group treated with SB-334867. There was no difference between the S groups treated with either SB-334867 or vehicle. The numbers of animals per group (N) and the legend for group coding shown in A apply to all panels.