Table 1.
UDA inhibition of SARS-CoV replication in Vero 76 cells.
| Virus strains | Neutral red (NR) assay |
Virus yield reduction assay |
|||
|---|---|---|---|---|---|
| IC50a (μg/ml) | CC50b (μg/ml) | SIc | IC90d (μg/ml) | Virus yielde | |
| Urbani | 2.6 ± 3.7 | 12.5 ± 4.4 | 10.2 ± 5.6 | 1.1 ± 0.4 | 4.8 ± 0.4 |
| Mouse-adapted virus | 0.6 ± 0.6 | 9.9 ± 0.2 | 42.8 ± 47.5 | 0.7 ± 0.7 | 5.3 ± 0.4 |
| Frankfurt v1940 | 2.0 ± 1.1 | 9.2 ± 1.0 | 5.5 ± 2.0 | 1.7 ± 1.1 | 5.1 ± 0.1 |
| Hong Kong v2157 | 1.7 ± 0.2 | 14.3 ± 0.6 | 8.6 ± 1.1 | 1.3 ± 0.2 | 5.4 ± 0.3 |
| Toronto-2 v2147 | 0.9 ± 1.2 | 9.5 ± 0.9 | 54.2 ± 52.5 | 0.9 ± 0.9 | 5.2 ± 0.4 |
a
50% virus inhibitory concentration.
b
50% cell cytotoxic concentration of drug.
c
Selective index: SI = CC50/IC50.
d
90% virus inhibitory concentration.
e
Average virus titers (log10 CCID50 per 0.18 ml).