Table 4.
Effects of UDA treatment on various measured lung parameters at day 3 post virus exposure for BALB/c mice infected with a lethal dose of SARS-CoV.
Treatment | Day 3 lung scores (g) ± SD | Day 3 lung weights (g) ± SD | Day 3 virus lung titers/g tissue ± SD |
---|---|---|---|
PSS | 1.70 ± 0.57 | 0.18 ± 0.03 | 6.31 ± 0.13 |
UDA (20 mg/kg/day) | 0.50 ± 0.35* | 0.18 ± 0.03 | 6.75 ± 0.35* |
UDA (10 mg/kg/day) | 0.30 ± 0.27** | 0.17 ± 0.01 | 6.75 ± 0.00* |
UDA (5 mg/kg/day) | 0.20 ± 0.27 | 0.18 ± 0.01 | 6.50 ± 0.20 |
Poly IC:LC (1 mg/kg) | 0.60 ± 0.22 | 0.17 ± 0.01 | 4.69 ± 0.13*** |
p < 0.05 versus PSS control.
p < 0.01 versus PSS control.
p < 0.001 versus PSS control.