Table 2.

Effect of hesperidin treatment (500 mg/d for 3 wk) on vascular function in study subjects who completed the entire study

Vascular parameters (n = 24)	Baseline	Placebo	Hesperidin	Treatment effects	P value
Systolic blood pressure (mm Hg)	138 ± 3	132 ± 2	134 ± 3	2.7 (−1.25, 6.66)	0.16
Diastolic blood pressure (mm Hg)	89 ± 2	90 ± 2	90 ± 2	0.6 (−2.1, 3.4)	0.64
FMD (%)	8.24 ± 0.88	7.78 ± 0.76	10.26 ± 1.19	2.47 (0.39, 4.55)	0.02
Nitroglycerin-mediated dilation (%)	13.98 ± 1.32	14.40 ± 1.02	14.04 ± 1.08	−0.35 (−1.03, 0.32)	0.30

Values shown at baseline and after treatment with placebo or hesperidin are expressed as mean ± sem or median (25th-75th percentile). After subtracting baseline observations, comparison of various posttreatment parameters was performed using crossover ANOVA. This analysis takes into account specific treatment arm, treatment order, and treatment effects. Treatment effects are expressed as mean (95% CI) or ratio (95% CI). P values are for posttreatment comparisons (placebo vs. hesperidin).