Table 4.

HR of cardiovascular and noncardiovascular mortality among participants of the Whitehall II study from phase 7 (2002–2004) through to January 2010 by z-scores of measures of cortisol before and after adjustment for covariates

	Noncardiovascular deaths		Cardiovascular deaths
	No. of events/total population	HR (95% CI)	No. of events/total population	HR (95% CI)
Slope in cortisola	106/4047	1.17 (0.96–1.43)	32/4047	1.87 (1.32–2.64)
Plus separate adjustment for
Smoking	106/3989	1.15 (0.94–1.40)	30/3974	1.96 (1.37–2.80)
Obese	103/4005	1.20 (0.98–1.47)	30/4005	1.92 (1.35–2.72)
Fasting glucose	99/3963	1.18 (0.96–1.45)	29/3963	2.00 (1.40–2.87)
Stress	96/3632	1.15 (0.93–1.42)	30/3632	1.77 (1.25–2.49)
Financial insecurity	104/3977	1.14 (0.93–1.39)	31/3977	1.96 (1.38–2.77)
Hours slept	101/3795	1.18 (0.96–1.46)	28/3795	1.86 (1.29–2.69)
Fatigue	102/3928	1.15 (0.93–1.41)	31/3997	1.93 (1.36–2.73)
Bedtime cortisola	105/3977	1.17 (0.96–1.44)	32/3977	1.98 (1.39–2.81)
Plus separate adjustment for
Smoking	105/3921	1.15 (0.94–1.41)	31/3921	1.99 (1.39–2.85)
Obese	102/3962	1.21 (0.98–1.49)	31/3962	2.01 (1.39–2.90)
Fasting glucose	98/3895	1.21 (0.98–1.49)	29/2895	2.15 (1.49–3.12)
Stress	95/3611	1.19 (0.96–1.47)	31/3611	1.91 (1.34–2.72)
Financial insecurity	103/3924	1.14 (0.93–1.40)	32/3924	1.97 (1.39–2.81)
Hours slept	100/3755	1.19 (0.96–1.45)	29/3755	2.07 (1.42–2.99)
Fatigue	102/3943	1.15 (0.93–1.41)	32/3943	1.93 (1.35–2.75)

Obese is classified as a BMI of 30 and over. Stress is the perceived stress, scored as follows: not at all = 1; somewhat = 2; moderate = 3; very = 4; and most stressed ever felt = 5. Financial insecurity is classified from a response of insecure or very insecure to a question on future perceived financial insecurity. Fatigue is defined as a score of 50 or less on the vitality subscale of the SF-36.

^aAdjusted for age, sex, employment grade, and time of sample collection since waking and waking time at phase 7 (2002–2004).