Figure 1.

Site of action of various antiplatelet drugs. Platelet activation inhibitors include (i) TXA2 pathway inhibitors which block either synthesis or receptors of TXA2, (ii) ADP receptor (P2Y12) inhibitors and (iii) thrombin receptor (PAR-1) inhibitors. Adhesion antagonists block interaction of collagen and vWF with GpVI and α2β1 receptors on platelets. GpIIb/IIIa Inhibitors block binding of fibrinogen to their receptors on platelets. ADP, adenosine diphosphate; PAR-1, protease activated receptor 1; TP, thromboxane receptor; TXA2, thromboxane A2; vWF, von Willebrand factor