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. Author manuscript; available in PMC: 2012 Apr 8.
Published in final edited form as: Mol Cell. 2011 Apr 8;42(1):118–126. doi: 10.1016/j.molcel.2011.03.006

Figure 4. Minor alterations of Sir2 and Sir3 binding at subtelomeric regions corresponded to observed gene expression changes.

Figure 4

A) The right arms of chromosome III and XIVR were plotted along the x axis against the relative occupancy (R/O) of Sir3 in a wild-type and dot1 deletion strain. Increased Sir3 occupancy coincided with a lower expression of AAD3 and COS10. B) The right arm of chromosome XIII was plotted along the x axis against the relative occupancy of Sir2 in a wild-type and dot1 deletion strain. Decreased Sir2 occupancy coincided with a higher expression of YMR323W. C) The left arms of chromosome VII and chromosome I were plotted along the x axis against the relative occupancy of Sir2 in a wild-type and dot1 deletion strain as well as H3K79 di- and trimethylation. Only minor changes in Sir2 occupancy were observed at the subtelomere of ChrVIIL and ChrIL in the absence of H3K79 methylation. The superimposed profiles with H3K79me2 and H3K79me3 indicate that COS12 and YAL067C were moderately enriched for H3K79 methylation and not Sir2.