Table 2.
Additional secondary efficacy outcomes (full analysis set)
| Tramadol/paracetamol (n = 128) | Tramadol (n = 128) | |
|---|---|---|
| Number of tablets/capsules taken | ||
| ≤2 | 4 (3.1%) | 5 (3.9%) |
| 3 | 12 (9.4%) | 9 (7%) |
| 4 | 11 (8.6%) | 17 (13.3%) |
| 5 | 12 (9.4%) | 14 (10.9%) |
| 6 | 29 (22.7%) | 29 (22.7%) |
| 7 | 41 (32%) | 31 (24.2%) |
| 8 | 10 (7.8%) | 14 (10.9%) |
| >8 | 9 (7%) | 9 (7%) |
| Time to first intake of trial medication (h) | 6.59 ± 1.82 | 6.73 ± 2.04 |
| Rescue medication (diclofenac 50 mg) | 22 (17.2%) | 17 (13.3%) |
| Time to first intake of rescue medication (h) | 25.6 ± 20.8 | 25.6 ± 20.0 |
| Antiemetic medication (metoclopramide) | 21 (16.4%) | 28 (21.9%) |
| Premature withdrawal due to lack of efficacy | 17 (13.3%) | 14 (10.9%) |
| Time to premature withdrawal due to lack of efficacy (h) | 12.8 ± 11.3 | 10.2 ± 9.0 |
Note: Data are mean ± SD or number of patients (%).