Table 3.

Summary of Top 30 findings from SNP x rAOS Interaction model – Top findings from each of 16 R² bins are presented

Rank	LD Bin	SNP	Gene	Chr	Position (Mb)	Minor Allele	Freq.	P-Main (Main Effect Model)	P-Joint (SNP, SNP x rAOS)	ΔAIC ³ (Main Effect Model)	ΔAIC (SNP, SNP x rAOS)	ΔC(%)⁴
1	1	rs17760877	GRIN2B	12	13.71	C	0.11	0.238236	0.000015	+0.6	−18.3	0.72
2	2	rs11693629	DBI	2	119.84	T	0.29	0.171475	0.000077	+0.1	−14.9	0.31
3	3	rs890	GRIN2B	12	13.61	G	0.49	0.081236	0.000086	−1.0	−14.7	0.57
4	4	rs16969968	CHRNA5	15	76.67	A	0.35	0.000440	0.000109	−10.4	−14.2	0.79
5	5	rs2314379	MAP3K4	6	161.39	T	0.43	0.000929	0.000142	−9.0	−13.7	0.20
7	6	rs10505566	ADCY8	8	131.95	C	0.21	0.331764	0.000173	+1.1	−13.3	0.28
9	7	rs17483548	IREB2¹	15	76.52	A	0.34	0.000355	0.000202	−10.8	−13.0	0.51
10	8	rs2289948	DBI	2	119.85	G	0.20	0.067328	0.000233	−1.3	−12.7	0.41
18	9	rs6517442	KCNJ6	21	38.21	C	0.31	0.000628	0.000413	−9.7	−11.6	0.26
19	10	rs2277091	AGPAT4	6	161.49	A	0.42	0.004145	0.000458	−6.2	−11.4	0.48
23	11	rs3025382	DBH	9	135.49	A	0.11	0.000326	0.000662	−10.9	−10.6	0.22
25	12	rs29202	VAPA	18	9.92	C	0.05	0.766735	0.000717	−8.2	−10.6	0.18
26	13	rs13433293	KCNB1	20	47.43	T	0.18	0.000368	0.000735	−10.7	−10.4	0.45
28	14	rs452667	GABRR1	6	89.96	T	0.19	0.575845	0.000785	−9.6	−10.3	0.22
29	15	rs1488	MAP3K4	6	161.46	G	0.36	0.000268	0.000849	−1.7	−10.3	0.39
30	16	rs12545452	ADCY8	8	131.85	T	0.36	0.582631	0.001001	−11.3	−10.1	0.48

Note: Italics indicate SNPs that are in moderate LD (R²=0.5 to 0.8) with more highly ranked SNPs P-Joint is derived from the interaction model analysis (Equation 3). P-Main is the p-value for the same SNP when analyzed without the interaction term (Equation 2).

Proximal to CHRNA5-A3-B4 Cluster.

Akaike’s information criterion compared with base model (Equation 1); lower values indicate better model fit.

⁴

Improvement in logistic regression concordance rate (cross-validated) on introducing SNP and SNP x rAOS into the model.