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. Author manuscript; available in PMC: 2012 Apr 12.
Published in final edited form as: Biochemistry. 2011 Mar 18;50(14):3025–3033. doi: 10.1021/bi101832w

Figure 5. Phylogenetic conservation of hNTAN1 Cys residues.

Figure 5

A PSI-BLAST search was carried out with the complete amino acid sequence of hNTAN1 (UniProtKB number: Q96AB6) at EMBL-EBI (http://www.ebi.ac.uk/Tools/sss/psiblast/). The “UniProt Knowledgebase” was selected as the Protein Database and the PSI-BLAST threshold was set to 10. An alignment of hNTAN1 with the PSI-BLAST results (n = 106) was generated with ClustalW2 (40) and used to evaluate the degree of conservation across each Cys residue in hNTAN1. Each plot depicts the residue identities and corresponding frequencies observed at the hNTAN1 Cys position denoted at the top of each plot. The italicized percentage value within each plot indicates the frequency of Cys (highlighted by red outline) across all sequences at the given hNTAN1 position.