Table 2.
Study characteristics.
| Study | N (pts) | HB target (g/dL) | ESA | GFR range (mL/min/1.73 m2) | Primary endpoint | P value for primary endpoints |
|---|---|---|---|---|---|---|
| CHOIR (2006) [10] | 603 | 13.5 versus 11.3 | Epoetin Alfa | 15–50 | Death, MI, CHF, CVA | 0.03 for composite favoring lower Hb |
| CREATE (2006) [22] | 1432 | 13–15 versus 10.5–11.5 | Epoetin Beta | 15–35 | Composite of 8 CV events, CKD progression | NS for CV events. 0.03 for ESRD favoring lower Hb group |
| TREAT (2009) [23] | 4038 | 13 versus 9 | Darbepoetin Alfa | 20–60 | Death, CV Event, ESRD | NS |