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. 2011 Mar 30;2011:482415. doi: 10.1155/2011/482415

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Copyright © 2011 Nicola Marchi et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Leakage of the BBB is associated with neonatal seizures. (a) Summary of the neurovascular changes induced by prenatal exposure to MAM and/or THAL. (b) Seizures in neonatal THAL-MAM rats displayed on a joint time-frequency plot. Note also the traces recorded by the scalp electrode. (c) Loss of selective BBB permeability is associated to brain edema and hemispheric asymmetry in THAL-MAM rats. Red arrows point to region of disrupted cytoarchitecture due to vascular edema. (c1) FITC-albumin is used to indicate loss of BBB integrity.