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Inhibition of nucleus-cytoplasm trafficking of macromolecules by PV 2Apro. (a and b) Proteins and RNAs (represented in the scheme by an mRNA) are imported and exported throughout the NPC by the mediation of FG nucleoporins (Nup98, Nup62, and Nup153) and import and export carriers. (c) However, cleavage of these nucleoporins by PV 2Apro induces the releasing of the FG domains impairing the interaction of these components of the NPC with the trafficking machinery.
