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(A) The demethylase capabilities of Lid can contribute to gene repression by removing H3K4me3 marks, which are associated with active genes [73-75]. (B) Binding of dMyc to Lid inactivates its demethylase activity but retains H3K4me3 binding ability, allowing it to recruit dMyc to actively transcribed genes [76,77]. (C) Lid represses Notch target genes by associating with the LAF complex and demethylating H3K4me3 [78,79].
