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(A) NotchICD activates genes by recruiting RBP-J and a histone acetyltransferase (HAT) complex that adds activating marks to histones, therefore allowing transcription on Notch target genes. In the absence of NotchICD, RBP2 can bind RBP-J and demethylate existing activating marks, leading to repression of Notch target genes [83]. (B) RBP2 has been shown to interact with the Sin3/HDAC complexes which are crucial targets for anti-cancer therapies [88-90].
