Table 1.
KDM5 family demethylases in cancer.
| Demethylase | Cancer type | Notes | Potential role |
|---|---|---|---|
|
| |||
| KDM5A/RBP2/JARID1A | gastric | overexpressed [91] | oncogene |
| leukemia | NUP98 fusion [97] | oncogene | |
| cervical | overexpressed [125] | oncogene | |
| lung | drug tolerance [99] | oncogene | |
|
| |||
| KDM5B/PLU1/JARID1B | breast | overexpressed [100] | oncogene |
| prostate | overexpressed [108] | oncogene | |
| bladder | overexpressed [107] | oncogene | |
| lung | overexpressed [107] | oncogene | |
| melanoma | tumor progression [113] | oncogene | |
|
| |||
| KDM5C/SMCX/JARID1C | cervical | mediator of human papillomavirus protein E2 [119] | tumor suppressor |
| kidney | inactivating mutations [8] | tumor suppressor | |
|
| |||
| KDM5D/SMCY/JARID1D | prostate | deleted [124] | tumor suppressor |