Figure 1. Anti-CTLA-4 and α4-1BB synergize in the context of FVAX.

Kaplan-Meier survival curves for mice challenged with 2.5×10⁴ B16-BL6 cells and vaccinated on days 3, 6 and 9 with 1×10⁶ of A) FVAX or B) GVAX intra-dermally and the indicated antibody or combination intra-peritoneally. Lack of survival was defined as death or tumor size >1000 mm³. Each curve represents 3 independent experiments of 10 mice per group. P values were calculated using the Log-rank (Mantel-Cox) test (* - p≤0.05, ** - p≤0.01, ***-p<0.001).