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Morphological changes of HDFs in culture. Young (a), presenescent (b), and senescent (c) HDFs compared to TRF-treated HDFs (d)–(f). Senescent HDFs lost their original fibroblastic shape by acquiring a flattened morphology (indicated by arrow) with increased in size of nucleus and cells. The morphology of TRF-treated HDFs resembled that of young cells with more spindle-shaped cells present. Micrographs are shown at 200x magnification.
