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Comparison of total DNA damage at various stages of cellular ageing measured by Comet assay. Damaged DNA was higher in senescent HDFs which was decreased with TRF treatment. aDenotes P < .05 compared to untreated young HDFs, bP < .05 compared to untreated presenescent HDFs, cP < .05 compared to untreated senescent HDFs, dP < .05 compared to TRF-treated young HDFs. Data are presented as mean ± SD, n = 6.
