Table 2.
ARIC Carotid MRI Study: flow cytometry profile of fibrous cap measures and flow cytometry measures, restricted to participants with max wall thickness ≥1.5 mm and lipid core present
| Flow cytometry variable | Mean cap thickness (n = 499) | Mean minimum cap thickness (n = 501) |
|---|---|---|
| Platelets | ||
| GP IIb, MFI | −0.02 (0.24) | −0.003 (0.81) |
| GP IIIa, MFI | −0.03 (0.15) | 0.01 (0.69) |
| P-selectin, % | 0.01 (0.67) | 0.01 (0.67) |
| P-selectin, MFI | 0.01 (0.60) | 0.004 (0.80) |
| CD40L, % | −0.01 (0.73) | −0.00 (0.99) |
| CD40L, MFI | −0.03 (0.04) | −0.02 (0.05) |
| Leukocytes | ||
| CD14, MFI | −0.003 (0.85) | −0.01 (0.39) |
| TLR-2, % | 0.02 (0.18) | 0.01 (0.45) |
| TLR-2, MFI | 0.01 (0.29) | −0.002 (0.85) |
| TLR-4, % | 0.03 (0.12) | 0.01 (0.26) |
| TLR-4, MFI | 0.001 (0.94) | 0.001 (0.96) |
| PSGL-1, MFI | 0.02 (0.30) | 0.003 (0.85) |
| MPO, MFI | 0.01 (0.55) | −0.003 (0.86) |
| Cellular aggregates | ||
| PMA, % | 0.03 (0.03) | 0.02 (0.13) |
Results are adjusted for age, race and gender, LDL-C, HDL-C, TG, CRP, BMI, waist/hip, diabetes, smoking, lipid-lowering therapy, antihypertensive medications (fibrous cap also adjusted for wall thickness).
Standardized beta coefficients, p value in parentheses. Number of SD differences in MRI variables associated with 1 SD increment in flow cytometry measures.