Table 3.
ARIC Carotid MRI Study: flow cytometry profile for continuous lipid core measures restricted to participants with max wall thickness >1.5 mm
| Flow cytometry variable | Total lipid core volume (n = 513) | Maximum lipid core area (n = 513) |
|---|---|---|
| Platelets | ||
| GP lib, MFI | −0.01 (0.74) | −0.002 (0.62) |
| GP Ilia, MFI | 0.02 (0.65) | −0.001 (0.90) |
| P-selectin, % | −0.04(0.18) | −0.01 (0.21) |
| P-selectin, MFI | −0.08 (0.03) | −0.01 (0.05) |
| CD40L, % | 0.01 (0.72) | 0.004 (0.30) |
| CD40L, MFI | 0.03 (0.25) | 0.003 (0.32) |
| Monocytes | ||
| CD14, MFI | 0.06(0.10) | 0.01 (0.06) |
| TLR-2, % | −0.00 (0.99) | 0.003 (0.53) |
| TLR-2, MFI | −0.02 (0.68) | 0.002 (0.74) |
| TLR-4, % | −0.01 (0.75) | −0.00 (0.97) |
| TLR-4, MFI | 0.04 (0.22) | 0.004 (0.44) |
| PSGL-1, MFI | −0.01 (0.83) | −0.001 (0.77) |
| MPO, MFI | −0.01 (0.66) | 0.001 (0.83) |
| Cellular aggregates | ||
| PMA, % | −0.03 (0.35) | −0.01 (0.15) |
Results are adjusted for age, race and gender, LDL-C, HDL-C, TG, CRP, BMI, waist/hip, diabetes, smoking, lipid-lowering therapy, antihypertensive medications (lipid core also adjusted for total wall volume).
Standardized beta coefficients, p value in parentheses. Number of SD differences in MRI variables associated with 1 SD increment in flow cytometry measures.