Table 3.

ORs and 95% CIs for the association between dietary variables and advanced colorectal adenoma stratified by genotype.

Dietary intake	Gene	Locus	Genotype	Cases/ controls	ORa	Pinteractionb	Correctedc Pinteraction
PhIP per 1,000 ng/day	CYP1B1	rs10012	CC	344/375	0.81 (0.58–1.12)	0.019	0.384
			CG	293/296	1.47 (0.93–2.30)
			GG	71/59	1.76 (0.60–5.21)
			CG/GG	364/355	1.53 (1.02–2.30)
	CYP1B1	rs1056836	CC	232/250	1.86 (1.07–3.22)	0.019	0.384
			CG	337/344	0.86 (0.64–1.15)
			GG	137/137	0.82 (0.33–2.08)
			CG/GG	474/481	0.85 (0.64–1.13)
	NQO1	rs1800566	CC	416/474	1.03 (0.76–1.40)	0.007	0.340
			CT	244/225	0.99 (0.60–1.61)
			TT	25/17	–
			CT/TT	269/242	0.80 (0.52–1.24)
B[a]P per 100 ng/day	CYP1B1	rs10012	CC	344/375	0.74 (0.55–1.00)	0.005	0.340
			CG	293/296	1.25 (0.94–1.68)
			GG	71/59	1.66 (0.73–3.81)
			CG/GG	364/355	1.29 (0.99–1.68)
	CYP3A4	rs2242480	GG	558/579	1.02 (0.83–1.21)	0.021	0.384
			GA	126/131	1.13 (0.69–1.85)
			AA	12/14	–
			GA/AA	138/145	0.89 (0.56–1.42)
Nitrate + Nitrite per 0.5 mg/day	CYP1A1	rs1048943	AA	646/684	1.03 (0.92–1.15)	0.022	0.384
			AG	44/38	1.11 (0.75–1.59)
			GG	2/3	–
			AG/GG	46/41	1.14 (0.79–1.64)

Data are limited to SNPs with statistically significant tests for interaction before correction.

^aAdjusted for age, gender and ethnicity.

^bLikelihood ratio test for model with cross-product terms of dietary variables (coded as continuous) with the genotype variables (coded as Dummy variables) compared to null model with only main effects for dietary variables and genotypes.

^cBased on false discovery rate.