Table 2.

Comparison of viral vector characteristics

	Adenovirus	Lentivirus	Adeno-associated virus
Vector particle size	70–90 nme	80–120 nmc	18–26 nme
Genome size	~ 36 Kbe	~ 10 Kbe	~ 5 Kbe
Space for cloned sequence	~ 8 Kbe	~ 10 Kbc	~ 5 Kbe
Genome structure	Linear dsDNAe	Linear ssRNA, + onlyc	Linear ssDNA, + or −e
Envelope	Nonee	VSVG glycoproteinc	Nonee
Latency to peak transgene expression	3–5 daysi,k	~7 daysj	~2–4 weekse
Rate limiting step before expression	DNA into nucleuse	Integration into host genomee	Second strand synthesise
Can integrate into host genome?	No, but in nucleuse	Yes, non-specifice	Yes, inefficiente
Expression requires integration?	Noe	Yese	Noe
Inflammatory?	Yesi	Noe	Noe
Duration of transgene expression	Weeks/monthse,i	Yearse	Yearse
Transduces post-mitotic cells?	Yese	Yesc	Yese
Neuronal transduction	Moderatei,j	Moderatea,d	Very strong b,f,h
Glial transduction	Strongi,j	Moderatea,g	Very minimal or noneb,f,h

^aBlits et al., 2010

^bBurger et al., 2004

^cEscors and Breckpot, 2010

^dHeger et al., 2007

^eHowarth et al., 2009

^fMason et al., 2010

^gMeunier and Pohl, 2009

^hPaterna et al., 2004

ⁱPuntel et al., 2010

^jSinnayah et al., 2002

^kVasquez et al., 2001