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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Cancer Res. 2011 Mar 17;71(9):3196–3201. doi: 10.1158/0008-5472.CAN-10-3471

Figure 2.

Figure 2

Combination of metformin with paclitaxel or carboplatin suppresses tumor growth and prolongs remission. A, Tumor volume (mean ± SD) in mice injected on day 0 with transformed ER-Src or MDA-MB-231 cancer cells that were untreated (NT), treated by intratumoral injections (days 10, 15, 20, 25) with 10 mg/kg paclitaxel (PTX) or treated with paclitaxel together with metformin diluted in drinking water (200 μg/ml). B, Tumor volume in mice injected with transformed ER-Src or MDA-MB-231 cancer cells that were untreated (NT), treated by intra-tumoral injections (days 10, 15, 20, 25) with 20 mg/kg carboplatin (CAR) or treated with carboplatin together with metformin diluted in drinking water (200ug/ml).