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Metformin is effective when combined with lower doses of doxorubicin. Tumor volume (mean ± SD) in mice injected on day 0 with the indicated cancer cells that were treated by intra-tumoral injections (days 10, 15, 20, 25) with 1 mg/kg doxorubicin, metformin diluted in drinking water (200 µg/ml) or both.
