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Metformin together with doxorubicin inhibit prostate and lung tumor growth. A, Tumor volume (mean ± SD) in mice injected on day 0 with PC3 prostate cancer cells or B, A549 lung cancer cells that were untreated (NT), treated by intra-tumoral injections (days 10, 15, 20, 25) with 1 or 4 mg/kg doxorubicin (DOX) together with metformin diluted in drinking water (200 μg/ml).
