Table 1.
Characteristics of Study Participants
| Controls ( n = 25) | CIND (n = 25) | |
|---|---|---|
| Demographics | ||
| Age (mean(SD) | 70.5 (8.2) | 72.4 (6.7) |
| Gender (female/male) | 14/11 | 8/17 |
| Years of Education (mean (SD) | 16.5 (2.6) | 15.6 (3.5) |
| Apo E4 carrier state (yes/no) | 7/18 | 11/14 |
| Neuropsychological Scores | ||
| MMSE (mean(SD)) | 29.6 (1.0) (range: 26–30) | 28.2 (1.8)* (range: 24–30) |
| IFRD (mean(SD)) | 2.3 (0.5) (range: 1.3–3.2) | 1.8 (0.5)* (range: 1.2–2.8) |
| SFRD (mean(SD)) | 2.4 (0.8) (range: 0.5–3.7) | 1.7 (0.8)* (range: 0–3.4) |
| DRD (mean(SD)) | 2.4 (0.7) (range: 0.9–3.7) | 1.6 (0.9) (range: −0.4–2.8) |
| Subfield Volumes (mm3) | ||
| ERC (mean(SD)) | 104.8 (25.1) (range: 56.5–151.5) | 94.6 (20.7) (range: 44.2–132.7) |
| Sub (mean(SD)) | 108.5 (21.7) (range: 70.0–144.2) | 108.2 (19.6) (range: 70.6–147.3) |
| CA1 (mean(SD)) | 201.9 (24.7) (range: 141.8–233.6) | 192.3 (39.0) (range: 93.8–258.4) |
| CA1-2 (mean(SD)) | 10.1 (1.4) (range: 8.0–13.5) | 9.6 (1.7) (range: 6.9–13.2) |
| CA3&DG (mean(SD)) | 148.3 (22.5) (range: 141.8–233.6) | 144.3 (26.7) (range: 99.2–212.1) |
*
p <0.05 lower than controls, SD, standard deviation. MMSE, mini mental state examination, IFRD, immediate free recall discriminability total score, SFRD, short free recall discriminability score; DRD, delayed free recall discriminability score. ERC, entorhinal cortex; Sub, subiculum; CA1, cornu ammonis sector 1; CA1-2, CA1-2 transition (cf. methods for definition); CA3&DG, combined cornu ammonis sector 3 and dentate gyrus. Volumes are corrected for ICV (cf. methods section)