Table 1.
| |||||||
---|---|---|---|---|---|---|---|
No. | R1 | R2 | R3 | R4 | X | Ke (nM) | |
OX1a | OX2b | ||||||
1 | 45±12 | 1194 | |||||
5 | 682.6±231 | >10,000 | |||||
9 | H | H | NO2 | N | >10,000 | nt | |
10 | H | Me | NO2 | CH | >10,000 | nt | |
11 | Cl | Me | NO2 | CH | >10,000 | nt | |
12 | Me | Me | NO2 | CH | >10,000 | nt | |
13 | OMe | Me | NO2 | CH | >10,000 | nt | |
14 | H | Me | H | H | CH | >10,000 | >10,000 |
15 | H | Me | Me | Me | CH | 356.7±89 | >10,000 |
16 | Me | Me | Me | Me | CH | 2561±266 | >10,000 |
17 | OMe | Me | Me | Me | CH | 3945±2517 | >10,000 |
18 | H | Me | H | Hexanoyl | CH | >10,000 | >10,000 |
19 | H | Me | H | 3-Ph-propyl | CH | 3278±639 | >10,000 |
20 | H | Me | Me | 3-Ph-propyl | CH | >10,000 | >10,000 |
21 | H | Me | H | Hexyl | CH | >10,000 | >10,000 |
22 | H | Me | Me | Hexyl | CH | 398±16 | >10,000 |
23 | H | H | Me | Me | N | 46.3±8 | >10,000 |
values are the mean of at least three independent experiments in duplicate.
values are the mean of at least two independent experiments in duplicate.
nt = not tested.