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. Author manuscript; available in PMC: 2012 May 15.
Published in final edited form as: Bioorg Med Chem Lett. 2011 Mar 21;21(10):2980–2985. doi: 10.1016/j.bmcl.2011.03.048

Table 3.

Activity of 8-fluoroquinoline urea analogues against OX1R and OX2R.

graphic file with name nihms283908t3.jpg
Ke (nM)
No. R OX1a OX2b
24 graphic file with name nihms283908t4.jpg 2.4±1.7 171±25
30 graphic file with name nihms283908t5.jpg 395.6±111 >10,000
31 graphic file with name nihms283908t6.jpg >10,000 >10,000
32 graphic file with name nihms283908t7.jpg 4.9±2 491±90
33 graphic file with name nihms283908t8.jpg 64.2±12 2410±250
34 graphic file with name nihms283908t9.jpg 13.4±9 1617±50
35 graphic file with name nihms283908t10.jpg 10.3±5 306±30
36 graphic file with name nihms283908t11.jpg 965±419 >10,000
37 graphic file with name nihms283908t12.jpg >10,000 >10,000
38 graphic file with name nihms283908t13.jpg 50.5±18 3199±207
39 graphic file with name nihms283908t14.jpg 4563±1797 >10,000
a

values are the mean of at least three independent experiments in duplicate.

b

values are the mean of at least two independent experiments in duplicate