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Schematic representation of regulation of EMT and invasion of breast cancer cells by PGI/AMF. The miR200s seem to play a key role in the induction of EMT by PGI/AMF. The complex relationship between miR200s, NF-κB, ZEB1/ZEB2 and E-cadherin, and their regulation by PGI/AMF might be crucial to the acquisition of EMT and aggressive behavior of breast cancer cells.
