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Antiviral Potencies in Cells Infected with HIV-1 Containing Wild-Type or Mutant Integrase Enzymes.a
| No. | CC50 (μM) | EC50 (μM, WT) | Mutantsb |
||
|---|---|---|---|---|---|
| G140S/Q148H | Y143R | N155H | |||
| 1 | N/A | 0.004 ± 0.002 | 425 x | 53 x | 35 x |
| 4b-1 | 291 ± 51 | 61 ± 9 | 2 x | 4 x | 3 x |
Data was obtained as indicated in the Supporting Information.
Fold-loss of potency relative to virus containing wild-type (WT) enzyme.
