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. Author manuscript; available in PMC: 2013 Jul 1.
Published in final edited form as: Neurobiol Aging. 2011 Jan 6;33(7):1389–1399. doi: 10.1016/j.neurobiolaging.2010.11.021

Fig. 1.

Fig. 1

Over-expression of 9G8 suppresses tau exon 10 inclusion. (a) Diagrams of mini-tau genes, pCI-SI9/SI10, comprising tau exons 9, 10 and 11 and part of intron 9 and intron 10, and pCI-SI9/LI10, containing a full length of intron 10. (b) Over-expression of 9G8 inhibited tau E10 inclusion concentration dependently. COS7 cells were co-transfected with pCI-SI9/SI10 and various amounts of pCEP4/9G8 for 48 h. Total RNA was subjected to RT-PCR for measurement of tau E10 splicing. The relative ratios of E10+/E10− were calculated and are shown in the graph. “Con” indicates cells transfected with pCI-SI9/SI10 alone. “pCEP4” indicates co-transfection with pCI-SI9/SI10 and the empty vector pCEP4.