Skip to main content
. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Anesthesiology. 2011 May;114(5):1180–1189. doi: 10.1097/ALN.0b013e31820efb19

Figure 1.

Figure 1

The pharmacological reversal of the mechanical manifestations of Opioid-induced hyperalgesia (OIH) using the selective 5-HT3 antagonist ondansetron (OND). Mice of the C57BL/6J strain were used after chronic morphine treatment (see Methods). In Panel A, data representing the measurement of mechanical withdrawal thresholds after a single subcutaneous administration (↑) of OND (2 mg/kg) or saline in morphine treated mice are presented. In Panel B, mice were subcutaneously administered saline or ondansetron (1 mg/kg) at the time of each of the bi-daily morphine injections during the 4-day morphine treatment period. Data are presented as the means +/− SEM; *** P < 0.001. Six mice were used in each group.